Zoledronic
acid, also known as zoledronate, is a medication used to treat a number of bone
diseases. These include osteoporosis, high blood calcium due to cancer, bone
breakdown due to cancer, and Paget’s disease of bone. It is given by injection
into a vein. Common side effects include fever, joint pain, high blood
pressure, diarrhea, and feeling tired. Serious side effects may include kidney
problems, low blood calcium, and osteonecrosis of the jaw. Use during pregnancy
may result in harm to the baby. It is in the bisphosphonate family of
medications. It works by blocking the activity of osteoclast cells and thus
decreases the breakdown of bone.
Hypercalcemia
Hypercalcaemia,
also spelled hypercalcemia, is a high calcium (Ca2+) level in the blood serum.
The normal range is 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L), with levels
greater than 2.6 mmol/L defined as hypercalcemia. Those with a mild increase
that has developed slowly typically have no symptoms. In those with greater
levels or rapid onset, symptoms may include abdominal pain, bone pain,
confusion, depression, weakness, kidney stones or an abnormal heart rhythm
including cardiac arrest.
Uses
This
medication is used to treat high blood calcium levels (hypercalcemia) that may
occur with cancer. Zoledronic acid is also used with cancer chemotherapy to
treat bone problems that may occur with multiple myeloma and other types of
cancer (such as breast, lung) that have spread to the bones. Zoledronic acid
belongs to a class of drugs known as bisphosphonates. It lowers high blood
calcium levels by reducing the amount of calcium released from your bones into
your blood. It also works by slowing the breakdown of your bones by cancer to
prevent bone fractures.
How to use Zoledronic Acid Vial
Read
the Patient Information Leaflet if available from your pharmacist before you
start receiving zoledronic acid and each time you get a treatment. If you have
any questions, ask your doctor or pharmacist.
Side Effects
Dizziness,
headache, tiredness, or flu-like symptoms (such as fever, chills, muscle/joint
aches) may occur. If any of these effects persist or worsen, tell your doctor
or pharmacist promptly.
Precautions
Before
using zoledronic acid, tell your doctor or pharmacist if you are allergic to
it; or to other bisphosphonates (such as alendronate, risedronate); or if you
have any other allergies. This product may contain inactive ingredients, which
can cause allergic reactions or other problems. Talk to your pharmacist for
more details.
Interactions
Drug
interactions may change how your medications work or increase your risk for
serious side effects. This document does not contain all possible drug
interactions. Keep a list of all the products you use (including
prescription/nonprescription drugs and herbal products) and share it with your
doctor and pharmacist. Do not start, stop, or change the dosage of any
medicines without your doctor's approval.
Overdose
If
someone has overdosed and has serious symptoms such as passing out or trouble
breathing, call 911. Otherwise, call a poison control center right away. US
residents can call their local poison control center at 1-800-222-1222. Canada
residents can call a provincial poison control center. Symptoms of overdose may
include: change in the amount of urine, muscle spasms, muscle weakness,
mental/mood changes, irregular heartbeat, seizures.
Storage
Consult
the product instructions and your pharmacist for storage details. Keep all
medications away from children and pets.
Related Links
https://en.wikipedia.org/wiki/Zoledronic_acid
https://en.wikipedia.org/wiki/Hypercalcaemia
#Zoledronic Acid #Hypercalcaemia
#Zometa 4mg 1s (TR) #Novartis #Zoldonat 4mg 1s #Natco #
Please
note:
The Content is not intended to be a substitute for professional medical advice,
diagnosis, or treatment. Always seek the advice of your physician or other
qualified health providers with any questions you may have regarding a medical
condition.