Denosumab (trade names Prolia and
Xgeva) is a human monoclonal antibody
for the treatment of osteoporosis, treatment-induced bone loss, metastases to
bone, and giant cell tumor of bone. Denosumab is contraindicated in people with
low blood calcium levels. The most common side effects are joint and muscle
pain in the arms or legs. Denosumab is a RANKL inhibitor, which works by
preventing the development of osteoclasts, which are cells that break down
bone. It was developed by the biotechnology company Amgen.
Osteoporosis
Osteoporosis
is a disease in which bone weakening increases the risk of a broken bone. It is
the most common reason for a broken bone among the elderly. Bones that commonly
break include the vertebrae in the spine, the bones of the forearm, and the
hip. Until a broken bone occurs there are typically no symptoms. Bones may
weaken to such a degree that a break may occur with minor stress or
spontaneously. After a broken bone, Chronic pain and a decreased ability to
carry out normal activities may occur.
Uses
Denosumab
is used to treat bone loss (osteoporosis) in people who have a high risk of
getting fractures. Osteoporosis causes bones to become thinner and break more
easily. Your chance of developing osteoporosis increases after menopause (in
women), as you age, if someone in your family has osteoporosis, or if you take
certain medications (such as prednisone) for long periods. This medication
works by slowing bone loss to help maintain strong bones and reduce the risk of
broken bones (fractures). Denosumab belongs to a class of drugs called
monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from
breaking down bone.
How to use Denosumab Syringe
Read
the Medication Guide provided by your pharmacist before you start using
denosumab and before each injection. If you have any questions, ask your doctor
or pharmacist.
Side Effects
Remember
that your doctor has prescribed this medication because he or she has judged
that the benefit to you is greater than the risk of side effects. Many people
using this medication do not have serious side effects.
Precautions
Before
using denosumab, tell your doctor or pharmacist if you are allergic to it; or
if you have any other allergies. This product may contain inactive ingredients
(such as latex), which can cause allergic reactions or other problems. Talk to
your pharmacist for more details.
Interactions
Drug
interactions may change how your medications work or increase your risk for
serious side effects. This document does not contain all possible drug
interactions. Keep a list of all the products you use (including prescription/non-prescription
drugs and herbal products) and share it with your doctor and pharmacist. Do not
start, stop, or change the dosage of any medicines without your doctor's
approval.
Overdose
If
someone has overdosed and has serious symptoms such as passing out or trouble
breathing, call 911. Otherwise, call a poison control center right away. US
residents can call their local poison control center at 1-800-222-1222. Canada
residents can call a provincial poison control center.
Storage
This
medication is given in a hospital or clinic or doctor's office and usually will
not be stored at home.
Related Links
https://en.wikipedia.org/wiki/Denosumab
https://en.wikipedia.org/wiki/Osteoporosis
https://www.webmd.com/drugs/2/drug-154217-1335/denosumab-subcutaneous/denosumab-injection/details#:~:text=Denosumab%20is %20used%20to%20treat,thinner%20and%20break%20more%20easily.
#Denosumab
#Osteoporosis #Prolia 60mg 1s (IT) #Prolia 60mg 1s (TR) #Xgeva 120mg 1s (IT) #Xgeva
120mg 1s (TR) #Amgen
Please note: The Content is not intended to be a substitute for
professional medical advice, diagnosis, or treatment. Always seek the advice of
your physician or other qualified health providers with any questions you may
have regarding a medical condition.